Biomechanics Laboratory
國立台灣大學醫學工程學系 —— 生物力學實驗室
國立台灣大學醫學工程學系 —— 生物力學實驗室
對於眼睛的仰賴越來越大,眼睛健康狀況越來越被重視⋯⋯
我們以眼睛為研究主軸,但不以此為限,讓生物力學有無限發揮的樂趣
Welcome to Ophthalmology Biomechanics Laboratory in National Taiwan University.
I'm Po-Jen, the leader of the OBL. I'm an engineer.
From an engineer's perspective, I lead the team in applying classical mathematical and physical tools to advance the diagnosis and treatment of ophthalmological conditions. Our research centers on the mechanical behavior of the eye, leveraging principles from classical and fluid mechanics. We conduct both static and dynamic analyses to uncover the intricate biomechanical properties of ocular tissues, which hold the key to understanding various eye disorders.
Currently, our primary focus is on the cornea, exploring its geometry, material properties, and response to mechanical forces. We aim to elucidate its role in maintaining visual clarity and its involvement in conditions such as keratoconus and glaucoma. In addition, we are developing innovative tools and methodologies, such as computational modeling and experimental validation, to enhance our understanding of corneal biomechanics.
Looking forward, we plan to broaden our research to include other ocular structures, such as the lens, iris, sclera, aqueous and vitreous chambers, retina, and optic disc. These investigations will encompass their unique mechanical properties, interactions with intraocular pressure, and responses to external stimuli. Our ultimate goal is to create a comprehensive mechanical model of the eye, which will serve as a foundation for developing more effective diagnostic techniques, surgical interventions, and treatment plans. By integrating engineering principles with ophthalmology, we aspire to contribute significantly to the field of vision science and improve patient outcomes.
Interesting: image analysis, data science, and wave application.
202206 首位博士生畢業。
20190201 New faculty, Po-Jen Shih, joins Department of Biomedical Enginggering, National Taiwan Uiversity
Diagnosis of early keratoconus is the difficult among corneal diseases. This disease occurs in adolescence; its early symptoms are not significant, but similar to astigmatism. That causes many potential children being misdiagnosed at the beginning. Clinically, it is common that some irregularity on corneal is found and becomes irreversible when this disease is confirmed. In such a situation, the mild patients have to wear contact lenses for correction entire life, and the severe ones must undergo cornea implant surgery to recover sight.
Our team focus on this issue about early diagnosis. Thus we measured the deformation of the cornea during the air puff from tonometer, and then we decoupled the geometric changes on the profiles. From the profiles, we obtained the six vibration modes and waveforms. To analyze the material strength of the cornea and distinguish types of corneal pattern, we designed more than one hundred parameters from these waveforms. Finally, we applied statistical analysis to find four key parameters among them. These four parameters have been confirmed and can help distinguish normal from keratoconus among our database.